期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 38, 期 7, 页码 831-838出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2004.12.016
关键词
free radicals; S-nitrosothiols; nitric oxide; nitrosation; transport
资金
- NIGMS NIH HHS [GM55792] Funding Source: Medline
This review will focus on the transport and intracellular formation of S-nitrosothiols in cell culture models. The major points made in this article are: (1) S-Nitrosothiols are actively metabolized by cells. (2) S-Nitrosothiols affect cells in ways distinctly different from those of nitric oxide and can act through mechanisms that do not involve the intermediacy of nitric oxide. (3) Some S-nitrosothiols (S-nitrosocysteine, S-nitrosohomocysteine) can be taken up into cells via amino acid transport system L, whereas others (S-nitrosoglutathione, S-nitroso-N-acetylpenicillamine) are not directly transported, but require the presence of cysteine and/or cystine before the nitroso functional group is transported. (4) Proteomic detection of intracellular S-nitrosothiols is currently possible only if cells are loaded with high levels of S-nitrosothiols, and methodological advances are required in order to examine the S-nitrosated proteome after exposure of cells to physiological levels of nitric oxide. (c) 2004 Published by Elsevier Inc.
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