期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 11, 期 4, 页码 326-329出版社
ELSEVIER SCI LTD
DOI: 10.1111/j.1469-0691.2005.01096.x
关键词
Acinetobacter baumannii; beta-lactamase; carbapenemase; class D beta-lactamase; OXA carbapenenases; resistance
Carbapenem resistance associated with class D beta-lactamases is an increasing problem in Acinetobacter baumannii. Most enzymes of this class reported so far belong to two subgroups, 1 and 2; however, a novel class D carbapenemase (OXA-51) has been reported recently which shares 56% and < 63% amino-acid identity with subgroups 1 and 2, respectively, and which belongs to a third subgroup. This study describes a further seven novel subgroup 3 beta-lactamases in carbapenem-resistant A. baumannii isolates from four continents.
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