期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
卷 134B, 期 1, 页码 1-5出版社
WILEY
DOI: 10.1002/ajmg.b.30154
关键词
Alzheimer's disease; BDNF; dementia; association study; APOE epsilon 4
资金
- NIA NIH HHS [U24AG21886, P30 AG10161, AG09215, AG 10124, U24 AG021886, R01 AG15819] Funding Source: Medline
Genes known to contribute to the genetic predisposition to Alzheimer's disease (AD) are active in pathways of neurodegeneration but explain only a minority of the genetic contribution to AD. A protein of importance in cerebral neurodegeneration is the brain-derived neurotrophic factor (BDNF). Variations in two single-nucleotide polymorphisms (SNPs) within the BDNF gene have previously been associated with AD, and one of these SNPs has also been associated with memory loss and affective disorders. We performed a case control study of three BDNF SNPs in 250 neuropathologically confirmed cases of AD and 194 unrelated controls. We did not find a significant association between the three BDNF SNPs studied and AD when evaluated individually or with haplotype analysis. Nor did BDNF genotype appear to affect the APOE epsilon 4 association with AD. The three SNPs studied were closely linked (D'=0.99 across the region). We discuss possible reasons for our failure to confirm the previously reported associations. (c) 2005 Wiley-Liss, Inc.
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