期刊
IUBMB LIFE
卷 67, 期 6, 页码 395-403出版社
WILEY
DOI: 10.1002/iub.1384
关键词
microtubule-associated proteins; actin-microtubule interaction; direct crosslinking
资金
- DBT BioCare Grant [BT/Bio-Care/07/10044/2013-2014]
The cytoskeletal polymersactin, microtubules, and intermediate filamentsare interlinked by coordinated protein interactions to form a complex three-dimensional cytoskeletal network. Association of actin filaments with microtubules is important for various cellular processes such as cell division, migration, vesicle and organelle transport, and axonal growth. Several proteins including signaling molecules, motor proteins, and proteins directly or indirectly associated with microtubules and actin are involved in bridging the cytoskeletal components. Microtubule-associated proteins (MAPs) belonging to the MAP1, 2, 4 family and Tau proteins have been identified as key players that directly crosslink the two cytoskeletons. This review summarizes the current understanding of the interactions of these MAPs with actin filaments and their role in forming the actin-microtubule network and further discusses how the in vitro reconstitution assays can be used to study the dynamics of coordinated networks. Understanding the mechanisms by which actin and microtubules interact is key to decipher cancer, wound healing, and neuronal regeneration. (c) 2015 IUBMB Life, 67(6):395-403, 2015
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据