期刊
SCIENCE
卷 308, 期 5719, 页码 248-251出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1105677
关键词
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The microenvironments of the thymus are generated by thymic epithelial cells (TECs) and are essential for inducing immune self-toterance or developing T cells. However, the molecular mechanisms that underlie the differentiation of TECs and thymic compartmentalization are not fully understood. Here we show that deficiency in the tumor necrosis factor receptor-associated factor (TRAF) 6 results in disorganized distribution of medullary TECs (mTECs) and the absence of mature mTECs. Engraftment of thymic stroma of TRAF6(-/-)embryos into athymic nude mice induced autoimmunity. Thus, TRAF6 directs the development of thymic stroma and represents a critical point of regulation for self-tolerance and autoimmunity.
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