期刊
JOURNAL OF CELL BIOLOGY
卷 169, 期 1, 页码 35-47出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200502104
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资金
- NCI NIH HHS [CA89810, R33 CA089810] Funding Source: Medline
- NCRR NIH HHS [P41 RR000862, RR00862] Funding Source: Medline
- NIGMS NIH HHS [R37 GM038839, GM38839, F32 GM066496, GM066496, R01 GM038839] Funding Source: Medline
We have dissected specialized assemblies on the Saccharomyces cerevisiae genome that help define and preserve the boundaries that separate silent and active chromatin. These assemblies contain characteristic stretches of DNA that flank particular regions of silent chromatin, as well as five distinctively modified histones and a set of protein complexes. The complexes consist of at least 15 chromatin-associated proteins, including DNA pol epsilon, the Isw2-Itc1 and Top2 chromatin remodeling proteins, the Sas3-Spt16 chromatin modifying complex, and Yta7, a bromodomain-containing AAA ATPase. We show that these complexes are important for the faithful maintenance of an established boundary, as disruption of the complexes results in specific, anomalous alterations of the silent and active epigenetic states.
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