期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 293, 期 1-2, 页码 241-250出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2005.01.008
关键词
glyceryl monooleate; drug delivery systems; cubic phase; swelling studies
Glyceryl monooleate/water cubic phase systems were investigated as drug delivery systems, using salicylic acid as a model drug. The liquid crystalline phases formed by the glyceryl monooleate (GMO)/water systems were characterized by polarizing microscopy. In vitro drug release studies were performed and the influences of initial water content, swelling and drug loading on the drug release properties were evaluated. Water uptake followed second-order swelling kinetics. In vitro release profiles showed Fickian diffusion control and were independent on the initial water content and drug loading, suggesting GMO cubic phase gels suitability for use as drug delivery system. (c) 2005 Elsevier B.V. All rights reserved.
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