期刊
ORGANIC LETTERS
卷 7, 期 8, 页码 1485-1487出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol050081+
关键词
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资金
- NIGMS NIH HHS [R01 GM053936] Funding Source: Medline
[GRAPHICS] The alpha-L-threofuranosyl nucleoside triphosphates of T, G, and D (tTTP, tGTP, and tDTP) were synthesized from the described 2'-O-DMT-protected derivatives using the Eckstein method, while the corresponding C derivative (tCTP) was prepared from the 2'-O-acetyl derivative. The prepared alpha-L-threofuranosyl nucleoside triphosphates, despite being one carbon shorter than the native 2'-deoxyfuranosyl nucleoside triphosphates, are effective substrates for selected DNA polymerases.
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