期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 17, 页码 9287-9296出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b02297
关键词
dual-targeting; mitochondria; photodynamic therapy; drug delivery; graphene oxide
资金
- NSFC [21474031, 21174040, 21025415]
- National Key Basic Research Program of China [2013CB834702]
- Fundamental Research Funds for the Central Universities, SCUT
Photodynamic therapy (PDT) has been recognized as a valuable treatment option for localized cancers. Herein, we demonstrate a cellular and subcellular targeted strategy to facilitate PDT efficacy. The PDT system was fabricated by incorporating a cationic porphyrin derivative (MitoTPP),onto the polyethylene glycol (PEG)-functionalized and folic acid-modified nanographene oxide (NGO). For this PDT system, NGO serves as the carrier for MitoTPP as well as the quencher for MitoTPP's fluorescence and singlet oxygen (O-1(2)) generation. Attaching a hydrophobic cation to the photosensitizer ensures its release from NGO at lower pH values as well as its mitochondria-targeting capability. Laser confocal microscope experiments demonstrate that this dual-targeted nanosystem could preferably enter the cancer cells overexpressed with folate receptor, and release its cargo MitoTPP, which subsequently accumulates in mitochondria. Upon light irradiation, the released MitoTPP molecules generate singlet oxygen and cause oxidant damage to the mitochondria. Cell viability assays suggest that the dual-targeted nanohybrids exhibit much higher,cytotoxicity toward the FR-positive cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据