期刊
HUMAN MOLECULAR GENETICS
卷 14, 期 -, 页码 R65-R76出版社
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddi113
关键词
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资金
- NCI NIH HHS [R01-CA-001815, R01-CA-096958, R01 CA075090, R01-CA-075090, R01 CA001815, R01 CA096958] Funding Source: Medline
- NIEHS NIH HHS [R21-ES-11672, R21 ES011672] Funding Source: Medline
The field of cancer epigenetics is evolving rapidly on several fronts. Advances in our understanding of chromatin structure, histone modification, transcriptional activity and DNA methylation have resulted in an increasingly integrated view of epigenetics. In response to these insights, epigenetic therapy is expanding to include combinations of histone deacetylase inhibitors and DNA methyltransferase inhibitors. Zebularine, an orally administerable DNA methyltransferase inhibitor, has been a very promising recent addition to our arsenal of potentially useful drugs for epigenetic therapy. Aberrant DNA methylation patterns provide three powerful diagnostic applications as classification markers, sensitive detection markers, and risk assessment markers. Classification studies continue to increase in marker complexity, now incorporating microarrays, high-throughput bisulfite genomic sequencing and mass spectrometry, as the field moves to human epigenome projects. Sensitive detection technology has expanded from primarily blood-based cancer detection to include applications on a wide diversity of sample sources and is now also making inroads as a molecular risk assessment tool.
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