期刊
NEUROIMAGE
卷 25, 期 3, 页码 916-925出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2004.12.022
关键词
autism; functional connectivity; dorsal stream; mirror neurons
资金
- NIDCD NIH HHS [R01 DC006155-04, R01 DC006155-03, R01 DC006155-02, R01-DC006155, R01 DC006155-01, R01 DC006155] Funding Source: Medline
- NIMH NIH HHS [5T34MH65183-3, R01 MH036840, R01-MH36840] Funding Source: Medline
Some recent evidence has suggested abnormalities of the dorsal stream and possibly the mirror neuron system in autism, which may be responsible for impairments of joint attention, imitation, and secondarily for language delays. The current study investigates functional connectivity along the dorsal stream in autism, examining interregional blood oxygenation level dependent (BOLD) signal cross-correlation during visuomotor coordination. Eight high-functioning autistic men and eight handedness and age-matched controls were included. Visually prompted button presses were performed with the preferred hand. For each subject, functional connectivity was computed in terms of BOLD signal correlation with the mean time series in bilateral visual area 17. Our hypothesis of reduced dorsal stream connectivity in autism was only in part confirmed. Functional connectivity with superior parietal areas was not significantly reduced. However, the autism group showed significantly reduced connectivity with bilateral inferior frontal area 44, which is compatible with the hypothesis of mirror neuron defects in autism. More generally, our findings suggest that dorsal stream connectivity in autism may not be fully functional. (c) 2004 Elsevier Inc. All rights reserved.
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