期刊
SCIENCE
卷 308, 期 5720, 页码 411-413出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1107511
关键词
-
资金
- NCI NIH HHS [P30 CA 21765] Funding Source: Medline
- NHLBI NIH HHS [P01 HL53749-03] Funding Source: Medline
- NIAMS NIH HHS [P01-AR39448] Funding Source: Medline
The Drosophila cuticle is essential for maintaining the surface barrier defenses of the fly. Integral to cuticle resilience is the transcription factor grainy head, which regulates production of the enzyme required for covalent cross-linking of the cuticular structural components. We report that formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3. Mice tacking this factor display defective skin barrier function and deficient wound repair, accompanied by reduced expression of transglutaminase 1, the key enzyme involved in cross-linking the structural components of the superficial epidermis. These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据