期刊
CANCER LETTERS
卷 221, 期 1, 页码 97-104出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2004.08.031
关键词
NADPH oxidase 1; reactive oxygen species; colon cancer
类别
A superoxide-producing enzyme, NADPH oxidase 1 (Nox1), dominantly expressed in the colon, is implicated in the pathogenesis of colon cancer. Immunohistochemistry showed that Nox1 was constitutively expressed in surface mucous cells. Adenomas and well differentiated adenocarcinomas up-regulated Nox1 expression. Ki-67-negative, well differentiated tumor cells contained abundant Nox1, whereas Ki-67-positive, proliferating cells did not express it. This differentiation-dependent expression in normal as well as tumor tissues suggests distinct roles of Nox1 besides mitogenic function. Nuclear factor (NF)-kappa B was predominantly activated in adenoma and adenocarcinoma cells expressing abundant Nox1, suggesting that Nox1 may stimulate NF-kappa B-dependent antiapoptotic pathways in colon tumors. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
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