期刊
TETRAHEDRON LETTERS
卷 46, 期 17, 页码 2997-3001出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.03.027
关键词
amination; copper catalysis; amino acid
Copper-catalyzed amination of aryl bromides and iodides under mild conditions has been developed with 2-dimethyl-aminoethanol as ligand and water as solvent. A variety of hydrophilic and hydrophobic aryl halide substrates have been aminated in good yield with a variety of amino acids, amino alcohols and peptides. This method has successfully N-arylated some hydrophilic amino compounds not available by other methods. (c) 2005 Published by Elsevier Ltd.
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