4.7 Article

Nocturnal activity with nighttime pergolide in Parkinson disease: A controlled study using actigraphy

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NEUROLOGY
卷 64, 期 8, 页码 1450-1451

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LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.WNL.0000158652.74601.48

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Pergolide is a dopamine agonist that improves Parkinson disease but is associated with dose-dependent sleepiness. This study evaluates the effect of a nighttime dose of 1 mg of pergolide on actigraphic measures of sleep using a randomized, double-blind, placebo-controlled study design. The pergolide group ( n = 10) worsened in actigraphic measures of sleep efficiency and sleep fragmentation vs the placebo group ( n = 12). Side effects were more frequent in the pergolide group.

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