期刊
AIDS
卷 19, 期 7, 页码 731-733出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.aids.0000166098.54564.0c
关键词
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资金
- FIC NIH HHS [R25 TW009337] Funding Source: Medline
- NIAID NIH HHS [R01 AI046148-08, AI-46148-03, R01 AI046148] Funding Source: Medline
- NIGMS NIH HHS [P01 GM066524, P01 GM066524-06] Funding Source: Medline
We have created a panel of recombinant HIV-1 infectious clones containing common patterns of reverse transcriptase (RT) mutations responsible I-or resistance to each of the currently available nucleoside reverse transcriptase inhibitors (NRTI), and we have submitted the panel to the National Institutes of Health AIDS Research and Reference Reagent Programme. Testing the activity of new antiretroviral compounds against this panel of drug-resistant clones will determine their relative activity against many clinically relevant NRTI -resistant viruses.
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