Determination of indomethacin in urine using molecule imprinting-chemiluminescence method

A soluble Mn (IV)-formaldehyde-indomethacin chemiluminescence system was found. Using a synthesized indomethacin MIP as recognition material and soluble Mn (IV)-formaldehyde-indomethacin as detection system, a new molecule imprinted-chemiluminesence method of determination of indomethacin was established. The response range of this method was between 1.0 x 10(-7) and 1.0 x 10(-5) g/mL with a linear correlation coefficient of 0.994. The detection limit was 4 x 10(-8) g/mL. The relative standard deviation for 5.0 x 10(-7) g/mL of indomethacin solution was 3.1% (n = 7). (c) 2004 Elsevier B.V. All rights reserved.