期刊
PSYCHIATRY RESEARCH
卷 134, 期 3, 页码 251-258出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2004.01.014
关键词
serotonin; cytokines; interferon; tumor necrosis factor; 5-HT2 receptor; mCPP; flesinoxan
类别
Serotonin (5-HT) is a neurotransmitter and immune modulator. The effect of 5-HT on the production of cytokines by human macrophages and lymphocytes is poorly recognized. In the present article we examine the role of 5-HT in. modulating the production of two pro-inflammatory cytokines, i.e. interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha), as well as the role of 5-HT1A and 5-HT2 receptors in this process. The specific aims were to examine the effects of 5-HT, p-chlorophenylalanine (PCPA), a 5-HT depleting agent, flesinoxan, a 5-HT1A agonist, m-chlorophenylpiperazine (mCPP), a 5-HT2B/2C agonist, and ritanserin, a 5-HT2A/2C antagonist, on the production of the above cytokines. We found that: (1) 5-HT, 15 mu g/ml, significantly decreased IL-6 and TNF alpha production; (2) pCPA, 5 mu M, significantly suppressed the production of IL-6 and TNF alpha; and (3) mCPP, 2.7 mu g/ml, significantly increased the production of IL-6 and TNF alpha. It is concluded that intracellular 5-HT is necessary for optimal synthesis of IL-6 and TNFot; 5-HT in physiological concentrations may increase IL-6 and TNFa production by stimulating 5-HT2 receptors; and extracellular 5-HT concentrations above the baseline physiological levels may suppress the production of the above cytokines. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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