期刊
EXPERIMENTAL AND MOLECULAR MEDICINE
卷 37, 期 2, 页码 128-132出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/emm.2005.17
关键词
IL10; polymorphism; tuberculosis
Interleukin 10 (IL10) is a powerful TH2-cell cytokine that inhibits lymphocyte replication and secretion of inflammatory cytokines. The genetic associations of polymorphisms in IL10 with clinical manifestations of tuberculosis (TB) were examined in a large number of patients with clinical TB infection (n = 459) and normal controls (n = 871). One common promoter SNP (IL10 -592 A > C) was found to be significantly associated with decreased risk of TB manifestation. The frequency of the C-bearing genotype was higher in normal controls than in patients with clinical TB infection (P = 0.005, OR = 0.69). A summary of the genetic effect of IL10 -1082 A > G, the other nearby promoter SNP, in other ethnic groups is also presented.
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