期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 129, 期 4, 页码 539-541出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1111/j.1365-2141.2005.05493.x
关键词
CD56; multiple myeloma; CNS involvement
类别
By immunohistochemistry, the CD56-positive myeloma cells were detected in three (38%) bone marrow (BM) and one (13%) cerebrospinal fluid (CSF) samples from eight patients with multiple myeloma involving the central nervous system (CNS MM). Of the three patients with CD56-positive BM myeloma cells, two had CSF myeloma cells negative for CD56. In a control cohort of 84 MM patients without CNS involvement, the BM myeloma cells were CD56-positive in 68 (80%) cases (P < 0.0001). The prevalence of CD56-negative myeloma cells in the BM and CSF of our patients suggests that CD56 downregulation may play a role in the pathogenesis of CNS MM.
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