期刊
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
卷 44, 期 2, 页码 113-119出版社
WILEY
DOI: 10.1016/j.femsim.2004.10.013
关键词
mucosal immunity; Th1-Th2 response; cytokines; Helicobacter pylori; chronic gastritis; peptic ulcer; gastric cancer; gastric lymphoma; autoimmunity
Helicobacter pylori infection is the major cause of gastroduodenal pathologies, but only a minority of infected patients develop chronic and life threatening diseases, as peptic ulcer, gastric cancer, B-cell lymphoma, or autoimmune gastritis. The type of host immune response against H. pylori is crucial for the outcome of the infection. A predominant H. pylori-specific Th1 response, characterized by high IFN-gamma, TNF-alpha, and IL-12 production associates with peptic ulcer, whereas combined secretion of both Th1 and Th2 cytokines are present in uncomplicated gastritis. Gastric T cells from MALT lymphoma exhibit abnormal help for autologous B-cell proliferation and reduced perforin- and Fas-Fas ligand-mediated killing of B cells. In H. pylori-infected patients with autoimmune gastritis cytolytic T cells infiltrating the gastric mucosa cross-recognize different epitopes of H. pylori proteins and H+K+ ATPase autoantigen. These data suggest that peptic ulcer can be regarded as a Th1-driven immunopathological response to some H. pylori antigens, whereas deregulated and exhaustive H. pylori-induced T cell-dependent B-cell activation can support the onset of low-grade B-cell lymphoma. Alternatively, If. pylori infection may lead in some individuals to gastric autoimmunity via molecular mimicry. (c) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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