期刊
CANCER BIOLOGY & THERAPY
卷 4, 期 5, 页码 506-508出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.4.5.1703
关键词
Fbw7; tumor suppressor; p53; c-Jun; cyclin E; c-Myc; Notch; ubiquitin; E3 ligase; cancer
类别
The F-box protein Fbw7/Sel-10/hCdc4/Ago, which is known to regulate ubiquitination and degradation of numerous important regulators of cell division and death including I Notch, cyclin E, c-Jun and c-Myc, has been recently rediscovered as a p53-dependent tumor suppressor. Delineation of the mechanisms of Fbw7 anti-oncogenic activities and of its inactivation in human cancers is expected to gain an important insight into tumorigenesis.
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