期刊
FASEB JOURNAL
卷 19, 期 7, 页码 729-738出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.04-3217com
关键词
fibrosis; cytokine; cell proliferation
资金
- NIGMS NIH HHS [GM 65603] Funding Source: Medline
All members of the Ctgf, Cyr61, and Nov (CCN) family share a high degree of sequence homology and conservation of structural motifs and domains. Here, we present data about a structure function analysis of connective tissue growth factor (CTGF), a prototypic member of the CCN family, which has been shown to be a downstream mediator of transforming growth factor-beta activities on fibroblasts. Our findings demonstrate the two domains of CTGF function to mediate two distinct biological effects. The N-terminal domain of CTGF mediates myofibroblast differentiation and collagen synthesis. The C-terminal domain of CTGF mediates fibroblast proliferation. These data provide a molecular basis for the divergence of CTGF actions on connective tissue cell types and suggest a model for functional analysis of all of the CCN family gene products.
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