期刊
ISRAEL JOURNAL OF CHEMISTRY
卷 56, 期 5, 页码 295-301出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ijch.201500025
关键词
apoptosis; Candida albicans; farnesol; metabolism; quorum sensing
资金
- University of Amsterdam
Quorum sensing (QS) molecules function within communities of single-cell organisms to allow concerted behavior in response to changing conditions, and certain criteria have been established to determine whether a particular molecule is quorum sensing or not. Farnesol has been identified as a secreted molecule responsible for the inoculum size effect in Candida albicans and synthetic farnesol has been used as a QS molecule in different studies. However, farnesol also exhibits growth inhibitory effects, and so a critical evaluation of farnesol is warranted. Here we review the literature to determine whether or not farnesol can indeed be considered a QS molecule in C. albicans.
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