期刊
CANCER CELL
卷 7, 期 5, 页码 469-483出版社
CELL PRESS
DOI: 10.1016/j.ccr.2005.04.023
关键词
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资金
- NCI NIH HHS [U01CA084291, R25-CA87812, P50-CA-62924, R01 CA101973] Funding Source: Medline
- NIA NIH HHS [K08 AG001019] Funding Source: Medline
- NIDDK NIH HHS [R01 DK60694] Funding Source: Medline
To define the genetic requirements for pancreatic ductal adenocarcinoma (PDA), we have targeted concomitant endogenous expression of Trp53(R172H) and Kras(G12D) to the mouse pancreas, revealing the cooperative development of invasive and widely metastatic carcinoma that recapitulates the human disease. The primary carcinomas and metastases demonstrate a high degree of genomic instability manifested by nonreciprocal translocations without obvious telomere erosion hallmarks of human carcinomas not typically observed in mice. No mutations were discovered in other cardinal tumor suppressor gene pathways, which, together with previous results, suggests that there are distinct genetic pathways to PDA with different biological behaviors. These findings have clear implications for understanding mechanisms of disease pathogenesis, and for the development of detection and targeted treatment strategies.
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