期刊
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION
卷 33, 期 3, 页码 169-176出版社
WILEY
DOI: 10.1002/bmb.2005.494033032470
关键词
allostery; monomeric proteins; myoglobin; albumin; thrombin
Multimeric proteins ( e. g. hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric proteins ( e. g. myoglobin) usually are assumed to be nonallosteric. However, the modulation of the functional properties of monomeric proteins by heterotropic allosteric effectors casts doubts on this assumption. Here, the allosteric properties of sperm whale myoglobin, human serum albumin, and human alpha-thrombin, generally considered as molecular models of monomeric proteins, are summarized.
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