期刊
TRENDS IN IMMUNOLOGY
卷 26, 期 5, 页码 235-238出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2005.03.007
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Over a decade ago endothelin-1 (ET-1) was described as belonging to the assortment of mast cell-derived and mast cell-bound cytokines. Mast cell subtype- and environment-dependent, ET-1 acts as a potent non-immunological mast-cell activator, which leads to degranulation and mediator release. The biological significance of this phenomenon remained obscure; however, a recent report sheds new light on this delicate mast cell-ET-1 connection. The authors of this report use mast cell-deficient mice to provide convincing evidence that mast cells counteract the toxicity induced by high concentrations of ET-1, and thereby promote homeostasis.
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