期刊
BIOCHEMICAL JOURNAL
卷 387, 期 -, 页码 561-571出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20041822
关键词
dicer; gene expression; gene silencing; PAZ Piwi domain protein (PPD protein); RNA-induced silencing complex (RISC); RNA interference (RNAi)
PPD (PAZ Piwi domain) proteins and the Dicer family have been the subjects of intense study over the last 6 years. These proteins have well-established roles in RNAi (RNA interference), a process that relies on siRNAs (small interfering RNAs) or miRNAs (microRNAs) to mediate specificity. The development of techniques for applying RNAi as a laboratory tool and a molecular therapeutic technique has rapidly outpaced our understanding of the biology of this process. However, over the last 2 years, great strides have been made towards elucidating how PPD proteins and Dicer regulate gene-silencing at the pre- and post-transcriptional levels. In addition, evidence is beginning to emerge that suggests that, these proteins have additional siRNA-independent roles as cell-cycle regulators. In the present review, we summarize the well-known roles of these two classes of proteins in gene-silencing pathways, as well as explore the evidence for novel roles of PPD and Dicer proteins.
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