期刊
NATURE NEUROSCIENCE
卷 8, 期 5, 页码 650-656出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1448
关键词
-
资金
- NHLBI NIH HHS [HL64582, R01 HL064582] Funding Source: Medline
- NIMH NIH HHS [F30 MH068087, MH68087] Funding Source: Medline
- NINDS NIH HHS [NS043169, R01 NS043169] Funding Source: Medline
In mammals, the precise circadian timing of many biological processes depends on the generation of oscillations in neural activity of pacemaker cells in the suprachiasmatic nucleus (SCN). The ionic mechanisms that underlie these rhythms are largely unknown. Using the mouse brain slice preparation, we show that the magnitude of fast delayed rectifier (FDR) potassium currents has a diurnal rhythm that peaks during the day. Notably, this rhythm continues in constant darkness, providing the first demonstration of the circadian regulation of an intrinsic voltage-gated current in mammalian cells. Blocking this current prevented the daily rhythm in firing rate in SCN neurons. Kv3.1b and Kv3.2 potassium channels were widely distributed within the SCN, with higher expression during the day. We conclude that the FDR is necessary for the circadian modulation of electrical activity in SCN neurons and represents an important part of the ionic basis for the generation of rhythmic output.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据