期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 14, 期 5, 页码 1326-1329出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-04-0815
关键词
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资金
- NCI NIH HHS [R01CA84141] Funding Source: Medline
To facilitate selection of single-nucleotide polymorphisms (SNP) for molecular epidemiologic studies investigating the hormonal carcinogenesis hypothesis, we used two sequence homology-based tools [Sort Intolerant from Tolerant (SIFT) and Polymorphism Phenotype (PolyPhen)] to predict the potential impact a nonsynonymous SNP (nsSNP), which results in an amino acid substitution, may have on the activity of proteins encoded by genes involved in the steroid hormone metabolism and response pathway. We screened 137 variants. Of these, 28% were predicted by SIFT and PolyPhen as having a potentially damaging effect on protein function. Investigation into the association of these variant alleles with hormone-related cancers may prove to be fruitful.
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