期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 140, 期 2, 页码 343-348出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1111/j.1365-2249.2005.02763.x
关键词
CHI3L1; endotoxin; HC-gp39; TNF-alpha; YKL-40
类别
YKL-40 is secreted by macrophages and neutrophils and patients with bacterial infections have elevated circulating YKL-40. The aim was to evaluate changes in plasma YKL-40 (determined by enzyme-linked immunosorbent assay (ELISA) at 0, 2, 4, 8, 24 and 32 h) in eight healthy volunteers after injection with Esherichia coli endotoxin or saline. Plasma YKL-40 increased after endotoxin injection from 31 mu g/l (range 19-39 mu g/l) to a maximum of 159 mu g/l (61-552 mu g/l, P < 0.01) at 24 h. The finding that plasma YKL-40 increased after endotoxin injection compared with saline (P < 0.001) suggests that YKL-40 has a functional role in infections.
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