期刊
CELL CALCIUM
卷 37, 期 5, 页码 483-488出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2005.01.017
关键词
Ca2+ channels; syntaxin; SNARE proteins; neurotransmission
类别
Calcium entry through presynaptic voltage-gated calcium channels is essential for neurotransmitter release. The two major types of presynaptic calcium channels contain a synaptic protein interaction site that physically interacts with synaptic vesicle release proteins. This is thought to tighten the coupling between the sources of calcium entry and the neurotransmitter release machinery. Conversely, the binding of synaptic proteins to presynaptic calcium channels regulates calcium channel activity. Hence, presynaptic calcium channels act not only as the masters of the synaptic release process, but also as key targets for feedback inhibition. (c) 2005 Elsevier Ltd. All rights reserved.
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