期刊
JOURNAL OF PSYCHOPHARMACOLOGY
卷 19, 期 3, 页码 301-305出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269881105051542
关键词
alcohol dependence; clozapine; craving; lamotrigine; schizophrenia
Comorbid alcohol dependence is common in patients with schizophrenia and is associated with a variety of serious adverse consequences. Although case reports exist concerning the positive impact of lamotrigine addition on clozapine treatment in resistant schizophrenia, a review of the literature fails to document any evidence regarding a combination of the two in the treatment of patients with schizophrenia and comorbid alcohol dependence. In the present study, we present three cases in which patients with resistant schizophrenia and comorbid alcohol use disorder were given lamotrigine to augment clozapine. Our findings suggest that clozapine plus lamotrigine may be helpful inreducing alcohol consumption and craving among patients with schizophrenia and comorbid alcohol dependence.
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