期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 129, 期 3, 页码 340-349出版社
WILEY
DOI: 10.1111/j.1365-2141.2005.05477.x
关键词
cellular therapies; dendritic cells; vaccines; acute myeloid leukaemia; cytotoxicity
类别
We assessed the potential of tumour cell/dendritic cell fusion hybrids to generate in vitro anti-leukaemic T-cell responses following co-culture with autologous remission lymphocytes in six patients with acute myeloid leukaemia (AML). Comparison was made to anti-leukaemic responses induced by mature dendritic cells (mDC) co-cultured with autologous, irradiated myeloid blasts. Fusion hybrids induced anti-leukaemic T- cell immune responses in three of six patients. Tumour-pulsed mDC induced T- cellular responses in two other patients. Only one of six patients remission lymphocytes failed to develop leukaemia-directed immune responses following stimulation with either construct. Anti-proliferative properties of fusion hybrids against allogeneic lymphocytes were observed in mixed lymphocyte-leukaemia reactions and were found not to be specific to the cell fusion partners and did not prevent the ability of AML-mDC heterokaryons to induce autologous anti-leukaemic cytotoxicity. We conclude that tumour cell/dendritic cell fusion hybrids hold promise as a cellular vaccine for AML.
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