期刊
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
卷 293, 期 1, 页码 404-410出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2005.02.061
关键词
MRI contrast agent; molecular imaging; nanoparticles; cancer; polyacrylamide (PAA); polyethylene glycol (PEG); photodynamic therapy (PDT)
A paradigm for brain cancer detection, treatment, and monitoring is established. Multifunctional biomedical nanoparticles (30-60nm) containing photosensitizer externally deliver reactive oxygen species (ROS) to cancer cells while simultaneously enhancing magnetic resonance imaging (MRI) contrast providing real-time tumor kill measurement. Plasma residence time control and specific cell targeting are achieved. A 5min treatment in rats halted and even reversed in vivo tumor growth after 3-4 days post-treatment. (c) 2005 Elsevier B.V. All rights reserved.
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