期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 35, 期 5, 页码 1592-1600出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/eji.200526119
关键词
cytokines; lymphoid organ development; host defense
类别
资金
- NCI NIH HHS [N01-CO-12400] Funding Source: Medline
We generated a novel tumor necrosis factor (TNF) null mutation using Cre-loxP technology. Mice homozygous for this mutation differ from their conventional counterparts; in particular, they completely lack Peyer's patches (PP) but retain all lymph nodes. Our analysis of these novel TNF-knockout mice supports the previously disputed notion of the involvement of TNF-TNFR1 signaling in PP organogenesis. Availability of TNF-knockout strains both with and without PP enables more definitive studies concerning the roles of TNF and PP in various immune functions and disease conditions. Here, we report that systemic ablation of TNF, but not the presence of PP per se, is critical for protection against intestinal Listeria infection in mice.
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