期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 162, 期 1-2, 页码 89-96出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2005.01.015
关键词
microglia; tumor necrosis factor-alpha (TNF-alpha); TNFR1(p55); TNFR2(p75)
In the central nervous system (CNS), tumor necrosis factor-alpha (TNF-alpha) derived from activated microglia plays a critical role as an inflammatory mediator. In this study, we examined the function of TNF-alpha as an autocrine mediator in microglial activation. TNF-alpha induced TNF-alpha production by microglia through ligation of TNF receptor 1 (TNFR1). TNF-alpha also increased the production of other inflammatory mediators. The activation of microglia by lipopolysaccharide is partially mediated by microglia-derived TNF-alpha. These findings suggest the existence of a positive feedback loop in the activation of microglia via TNF-alpha. This autocrine loop may be involved in the prolonged activation of microglia. (C) 2005 Elsevier B.V All rights reserved.
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