期刊
INTERNATIONAL JOURNAL OF HYPERTHERMIA
卷 21, 期 3, 页码 247-257出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/02656730500052027
关键词
cytokine; immunotherapy; in situ vaccination; microwave; tumour coagulation
After local microwave coagulation and subsequent intra-tumoural injection of microparticles encapsulating interleukin-2 and granulocyte-macrophage colony-stimulating factor, the anti-tumour efficacy against subcutaneous Lewis lung carcinoma in syngeneic mice was evaluated. This treatment elicited a potent systemic anti-tumour immunity that protected treated mice from re-challenge with the same tumour cells and caused the distal tumours in a bilateral tumour model to be rejected. Cytotoxicity assay indicated that both T- and natural killer cells acted as the effector cells in the anti-tumour immunity. These data highlight the feasibility of microwave- pre-treated in situ cancer vaccination for clinical use.
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