期刊
EXPERT OPINION ON THERAPEUTIC PATENTS
卷 15, 期 5, 页码 555-573出版社
ASHLEY PUBLICATIONS LTD
DOI: 10.1517/13543776.15.5.555
关键词
FK-506; FKBP; FKBP-12; FKBP-52; immunophilin; neurodegenerative disease; tacrolimus; rapamycin
Immunophilins are a family of binding proteins that are highly conserved in nature and mediate the actions of immunosuppressant drugs. The FK-506-binding protein (FKBP) subclass of immunophilin bind FK-506 and rapamycin and are of particular interest due to their potent neurotrophic activity. Here, the patent literature covering the structures of novel non-immunosuppressant derivatives of FK-506 and rapamycin, and their claims pertaining to their potential use for the treatment of neurological disorders, are reviewed.
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