期刊
THEORETICAL POPULATION BIOLOGY
卷 67, 期 3, 页码 141-160出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.tpb.2004.11.001
关键词
modifier genes; genetic interactions; modularity; evolvability; linkage and selection
资金
- NIGMS NIH HHS [GM28016] Funding Source: Medline
One interpretation of recent literature on the evolution of phenotypic modularity is that evolution should act to decrease the degree of interaction between genes that contribute to different phenotypes. This issue is addressed directly here using a fitness scheme determined by two genetic loci and a third locus which modifies a measure of statistical interaction between the fitnesses due to the first two. The equilibrium structure of such an epistasis-modifying locus is studied. It is shown that under well-specified conditions a modifying allele that increases epistasis succeeds. In other words, genetic interactions tend to become stronger. It is speculated that this occurs because the mean fitness in such models is locally increasing as a function of the degree of epistasis. (c) 2005 Elsevier Inc. All rights reserved.
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