期刊
WOUND REPAIR AND REGENERATION
卷 13, 期 3, 页码 230-236出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1067-1927.2005.130303.x
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资金
- NIAMS NIH HHS [AR02212] Funding Source: Medline
- NIDDK NIH HHS [DK59154] Funding Source: Medline
A neuropathic foot ulcer is a severe complication of diabetes that can result in a more severe complication, a lower extremity amputation. We conducted a cohort study of 24,616 individuals with a diabetic neuropathic foot ulcer treated within a multicenter wound care network. A total of 1653 (6.7%) individuals had an amputation and 46.3% of these amputations were of a toe or ray (minor amputation). In the more than 10-year follow-up period that we studied, the percentage of those who had an amputation varied between 5.6% and 8.4%. Of those who had an amputation, the percentage that had a minor amputation increased over time from 4.0% in the earliest years to more than 60% in the later years of observation. The single most important determinant of amputation was the observation of fascia, tendon, and bone at the initial assessment. In conclusion, about 7% of those with a diabetic neuropathic foot ulcer will have an amputation and in the past 10 years there has been a remarkable increase in the number of minor as compared to major amputations.
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