期刊
JOURNAL OF VIROLOGY
卷 79, 期 9, 页码 5499-5506出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.79.9.5499-5506.2005
关键词
-
类别
资金
- NCI NIH HHS [R01 CA067372, CA67372] Funding Source: Medline
- NCRR NIH HHS [P20 RR018724, P20RR18724] Funding Source: Medline
Control of translation initiation is one means by which cells regulate growth and proliferation, with components of the protein-synthesizing machinery having oncogenic potential. Expression of latency protein LMP2A by the human tumor virus Epstein-Barr virus (EBV) activates phosphatidylinositol 3-kinase/Akt located upstream of an essential mediator of growth signals, mTOR (mammalian target of rapamycin). We show that mTOR is activated by expression of LMP2A in carcinoma cells, leading to wortmannin- and rapamycin-sensitive inhibition of the negative regulator of translation, eukaryotic initiation factor 4E-binding protein 1, and increased c-Myc protein translation. Intervention by this DNA tumor virus in cellular translational controls is likely to be an integral component of EBV tumorigenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据