期刊
CEREBRAL CORTEX
卷 15, 期 5, 页码 545-551出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhh155
关键词
auditory; change-detection; fMRI; MMN; pre-attentive
资金
- NIMH NIH HHS [MH 65350, MH 63434] Funding Source: Medline
- NINDS NIH HHS [NS 30029] Funding Source: Medline
Electrophysiological studies have revealed a pre-attentive change-detection system in the auditory modality. This system emits a signal termed the mismatch negativity (MMN) when any detectable change in a regular pattern of auditory stimulation occurs. The precise intracranial sources underlying MMN generation, and in particular whether these vary as a function of the acoustic feature that changes, is a matter of some debate. Using functional magnetic resonance imaging, we show that anatomically distinct networks of auditory cortices are activated as a function of the deviating acoustic feature - in this case, tone frequency and tone duration - strongly supporting the hypothesis that MMN generators in auditory cortex are feature dependent. We also detail regions of the frontal and parietal cortices activated by change-detection processes. These regions also show feature dependence and we hypothesize that they reflect recruitment of attention-switching mechanisms.
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