期刊
BLOOD REVIEWS
卷 19, 期 3, 页码 153-164出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.blre.2004.06.003
关键词
hematopoietic cell transplantation; nonmyeloablative; chimerism; engraftment
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资金
- NCI NIH HHS [P01 CA078902, CA18029, CA78902, CA15704] Funding Source: Medline
- NHLBI NIH HHS [HL36444] Funding Source: Medline
- NIDDK NIH HHS [DK42716] Funding Source: Medline
Nonmyeloablative or reduced-intensity conditioning regimens have been used to condition elderly or ill patients with hematological malignancies for allogeneic hematopoietic cell transplantation (HCT). Initial mixed donor/host chimerism (i.e. the coexistence of hematopoietic cells of host and donor origin) has been observed in most patients after such transplants. Here, we describe both factors affecting engraftment kinetics in patients given a nonmyeloablative or a reduced-intensity conditioning, and associations between peripheral blood cell subset chimerism levels and HCT outcomes. (c) 2004 Elsevier Ltd. All rights reserved.
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