期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 60, 期 1, 页码 123-131出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2005.01.005
关键词
amphiphilic cyclodextrins; fluoroalkylthio-beta-cyclodextrins; alkylthio-beta-cyclodextrins; nanospheres; PCS; SEM; Cryo-TEM
This work describes the synthesis of new amphiphilic perfluorohexyl- and perfluorooctyl-propanethio-beta-cyclodextrins and the comparison of the ability of these molecules and alkyl analogue, nonanethio-beta-cyclodextrin to form nanospheres. Nanospheres were prepared using nanoprecipitation method (perfluoroalkylthio-beta-cyclodextrin in THF [0.11 X 10(-3)M], stirring rate 700 rpm, addition of aqueous phase at 64 degrees C into organic phase at 50 degrees C). They were characterised by Photon Correlation Spectroscopy (PCS) and by electron microscopy (SEM and cryo-TEM). The nanospheres prepared from these new beta-cyclodextrin derivatives have an average size of 260 nm, and appear to be spherical in cryo-TEM images. Whereas alkyl analogue forms polydisperse aggregates with sizes in the range 60-350 nm. (c) 2005 Elsevier B.V. All rights reserved.
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