期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 43, 期 5, 页码 2494-2496出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.43.5.2494-2496.2005
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We tested 109 unique, vancomycin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) strains for vancomycin heteroresistance by a selection method, i.e., step-wise exposure of large inoculums to increasing concentrations of vancomycin. Although no strains demonstrated stable beteroresistance, 81 strains (74%) demonstrated unstable heteroresistance. Unstable heteroresistance is common among clinical isolates of MRSA and may represent a cause of therapeutic failure.
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