期刊
JOURNAL OF NEUROCHEMISTRY
卷 93, 期 3, 页码 762-765出版社
WILEY
DOI: 10.1111/j.1471-4159.2005.03134.x
关键词
alpha 7 nicotinic acetylcholine receptor; basal ganglia; glia-neuron interactions; kynurenines; neurodegenerative diseases; schizophrenia
资金
- NICHD NIH HHS [HD 16596] Funding Source: Medline
Precise regulation of dopaminergic activity is of obvious importance for the physiology and pathology of basal ganglia. We report here that nanomolar concentrations of the astrocyte-derived neuroinhibitory metabolite kynurenic acid (KYNA) potently reduce the extracellular levels of striatal dopamine in unanesthetized rats in vivo. This effect, which is initiated by the KYNA-induced blockade of alpha 7 nicotinic acetylcholine receptors, highlights the functional relevance of glia-neuron interactions in the striatum and indicates that even modest increases in the brain levels of endogenous KYNA are capable of interfering with dopaminergic neurotransmission.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据