期刊
NEUROBIOLOGY OF AGING
卷 26, 期 5, 页码 637-643出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2004.06.003
关键词
apoE; anxiety; amygdala; MAP-2; Alzheimer's disease
资金
- NCRR NIH HHS [5 M01 RR000334] Funding Source: Medline
- NIA NIH HHS [AG-NS-0201, P30 AG08017, R01 AG20904] Funding Source: Medline
Increased anxiety may occur in up to 70% of AD patients during the course of their illness. Here we show that human apoE isoforms, which differ in AD risk, have differential effects on measures of anxiety in adult Apoe(-/-) male mice expressing human apoE3 or apoE4 in their brains and male probable AD (PRAD) patients. Compared with wild-type mice, Apoe(-/-) mice without human apoE or with apoE4, but not apoE3, showed increased measures of anxiety. These behavioral alterations were associated with reduced microtubule associated protein 2-positive neuronal dendrites in the central nucleus of the amygdala. Consistent with the mouse data, male and female PRAD patients with epsilon4/epsilon4 showed higher anxiety scores than those with epsilon3/epsilon3. We conclude that human apoE isoforms have differential effects on measures of anxiety. (C) 2004 Elsevier Inc. All rights reserved.
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