期刊
INTERNATIONAL REVIEWS OF IMMUNOLOGY
卷 24, 期 3-4, 页码 211-226出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/08830180590934976
关键词
CD25; Foxp3; immunoregulation; immunologic self-tolerance; IPEX; regulatory T cells
类别
Naturally arising CD25(+)CD4(+) regulatory T cells play key roles in the maintenance of immunologic self-tolerance and negative control of various immune responses. The majority, if not all, of them are produced by the normal thymus as a functionally distinct T-cell subpopulation, and their generation is in part developmentally controlled. Genetic abnormality in the development and function of this population can indeed be a cause of autoimmune disease, immunopathology, and allergy in humans. This regulatory population can be exploited to prevent and treat autoimmune disease by strengthening and reestablishing immunologic self-tolerance.
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