期刊
CLINICA CHIMICA ACTA
卷 355, 期 1-2, 页码 91-96出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cccn.2004.12.011
关键词
oxidative stress; nephrotic syndrome; thiol; free iron
Background: Albumin is a potent antioxidant as it chelates transitional metals and contains antioxidants like thiol and bilirubin. In neprotic syndrome, the defining parameter is proteirturia with hypoalbuminemia. Therefore alburninuria in nephrotic syndrome may increase toxic transitional metal ions and also can cause loss of albumin associated antioxidants causing oxidative stress to the individual. Methods: We investigated this possibility and estimated some markers of oxidative stress in 20 nephrotic syndrome patients and healthy controls along with urinary thiols, urinary bilirubin and plasma free iron in both cases and in the controls. Result: We found oxidative stress in 20 nephrotic syndrome patients and the markers of oxidative stress correlated significantly with proteinuria, but the urine of nephrotic syndrome patients (28.33 +/- 4.2 mu mol/g creatinine)contained significantly less thiols compared to the healthy controls (88.45 +/- 10.6 Rmol/g creatinine) and no biliribin. The patients plasma also showed free iron (0.7 +/- 0.05 mu mol/l), a parameter undetectable in the healthy controls. Conclusion: We suggest that oxidative stress and presence of free iron in the patients were responsible for less thioluria and no bilirubinuria. A detailed study of oxidative biology in a large cohort of nephrotic syndrome patients is necessary to confirm the presence of free iron as appropriate chelation of free iron may benefit the long-term prognosis of the disease. (c) 2005 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据